Cayman Hellebrin

Hellebrin is a cardiac glycoside that potently inhibits the Na⁺/K⁺-ATPase by binding to it and blocking its non-canonical function as a receptor for cardiac glycosides.^, Hellebrin has a higher affinity for the α₁β₁ subunit of the Na⁺/K⁺-ATPase than the α₂β₁ or α₃β₁ complexes, in contrast to other cardiac glycosides. This affinity for the α₁β₁ complex correlates with its cancer cell growth inhibition (GI₅₀ = 6-58 nM in various human cancer cell lines). Hellebrin also induces caspase-dependent apoptosis in Jurkat T cells.

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