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Cayman AN2728
List Price $238.00 Your Price $238.00
Cayman AN2728 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-21455-100
MFG.PART: 21455-100
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
AN2728 is a boron-based, topical anti-inflammatory agent that inhibits phosphodiesterase 4 (PDE4; IC50 = 0.11 µM). It is less potent against PDE1A, PDE3A, and PDE7A (IC50s = 6.12, 6.41, and 0.73 µM, respectively). AN2728 suppresses the release of the proinflammatory cytokines TNF-α, IL-2, INF-γ, IL-5, and IL-10 with IC50 values of 0.50, 0.59, 0.72, 2.25, and 2.58 µM, respectively.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[(1,3-
CAS Number
906673-24-3
Synonyms
- Crisaborole
Molecular Formula
C14H10BNO3
Formula Weight
251.1
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 25 mg/mL
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
- Ethanol: 25 mg/mL
λmax
251 nm
SMILES
OB(OC1)C(C1=C2)=CC=C2OC3=CC=C(C#N)C=C3
InChi Code
InChI=1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2
InChi Key
USZAGAREISWJDP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21455-100 |
|---|---|
| Supplier Part Number | 21455-100 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 906673-24-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |