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Cayman UCPH-101
List Price $127.00 Your Price $127.00
Cayman UCPH-101 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-21460-1
MFG.PART: 21460-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
UCPH-101 is a noncompetitive inhibitor of excitatory amino acid transporter 1 (EAAT1), which takes up extracellular glutamate in the central nervous system., UCPH-1 is selective for EAAT1 over EAAT2 and EAAT3 with IC50 values of 0.66, >300, and >300 µM, respectively, in a radioligand uptake assay using HEK293 cells transfected with the human transporter. It selectively inhibits anion currents in tsA201 cells expressing human EAAT1 (Kd = 0.34 µM) over rat EAAT4 and mouse EAAT5 at concentrations up to 10 µM. UCPH-101 is orally bioavailable in rats at a dose of 10 mg/kg but does not cross the blood-brain barrier.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-amino-5,6,7,8-
CAS Number
1118460-77-7
Molecular Formula
C27H22N2O3
Formula Weight
422.5
Purity
≥98% (mixture of isomers)
Formulation
A solid
Solubility
- DMF: 30 mg/mL
- DMF:PBS (pH 7.2)(1:3): 0.25 mg/mL
- DMSO: 25 mg/mL
λmax
225, 282 nm
SMILES
COC(C=C1)=CC=C1C2C(C#N)=C(N)OC3=C2C(C[C@@H](C4=C(C=CC=C5)C5=CC=C4)C3)=O
InChi Code
InChI=1S/C27H22N2O3/c1-31-19-11-9-17(10-12-19)25-22(15-28)27(29)32-24-14-18(13-23(30)26(24)25)21-8-4-6-16-5-2-3-7-20(16)21/h2-12,18,25H,13-14,29H2,1H3/t18-,25?/m1/s1
InChi Key
YBMGNDPBARCLFT-YDONVPIESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21460-1 |
|---|---|
| Supplier Part Number | 21460-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1118460-77-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |