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Cayman PHA-848125
List Price $69.00 Your Price $69.00
Cayman PHA-848125 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-21474-1
MFG.PART: 21474-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
PHA-848125 is an ATP-competitive inhibitor of cyclin-dependent kinases (Cdks) that potently inhibits Cdk2/cyclin A (IC50 = 45 nM). It is at least 3-fold less potent at Cdks 1, 3, 4, 5, and 7. PHA-848125 is orally available and displays efficacy in suppressing the growth of cancer cells or tumor xenografts in animals.,,
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4,5-dihydro-
CAS Number
802539-81-7
Synonyms
- Milciclib
Molecular Formula
C25H32N8O
Formula Weight
460.6
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 5 mg/mL
- DMSO: 10 mg/mL
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
λmax
295 nm
SMILES
[H]N(C1=NC(C(N(C)N=C2C(N(C)[H])=O)=C2C(C)(C)C3)=C3C=N1)C(C=C4)=CC=C4N5CCN(C)CC5
InChi Code
InChI=1S/C25H32N8O/c1-25(2)14-16-15-27-24(29-20(16)22-19(25)21(23(34)26-3)30-32(22)5)28-17-6-8-18(9-7-17)33-12-10-31(4)11-13-33/h6-9,15H,10-14H2,1-5H3,(H,26,34)(H,27,28,29)
InChi Key
RXZMYLDMFYNEIM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21474-1 |
|---|---|
| Supplier Part Number | 21474-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 802539-81-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |