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Cayman SPHINX31
List Price $41.00 Your Price $41.00
Cayman SPHINX31 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-21582-1
MFG.PART: 21582-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50 = 5.9 nM). It is selective for SRPK1 over a panel of 50 kinases at a concentration of 1 μM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1), an SRPK1 substrate, in PC3 cells (EC50 = 360 nM) and increases expression of the anti-angiogenic VEGF-A165b splice variant in retinal pigment epithelial (RPE) cells. In vivo, SPHINX31 (2 μg per eye) inhibits blood vessel growth and macrophage infiltration in the eyes of a mouse model of choroidal neovascularization.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-(4-
CAS Number
1818389-84-2
Molecular Formula
C27H24F3N5O2
Formula Weight
507.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 33 mg/mL
- DMF:PBS (pH7.2) (1:30): 0.03 mg/mL
- DMSO: 10 mg/mL
- Ethanol: 10 mg/mL
λmax
269, 317 nm
SMILES
O=C(C1=CC=C(C2=CC=NC=C2)O1)NC(C=C(C(F)(F)F)C=C3)=C3N(CC4)CCN4CC5=CC=CC=N5
InChi Code
InChI=1S/C27H24F3N5O2/c28-27(29,30)20-4-5-23(35-15-13-34(14-16-35)18-21-3-1-2-10-32-21)22(17-20)33-26(36)25-7-6-24(37-25)19-8-11-31-12-9-19/h1-12,17H,13-16,18H2,(H,33,36)
InChi Key
VURLRACCOCGFDB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21582-1 |
|---|---|
| Supplier Part Number | 21582-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1818389-84-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |