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Cayman BAY 12-17389
List Price $41.00 Your Price $41.00
Cayman BAY 12-17389 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-21660-1
MFG.PART: 21660-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
BAY 12-17389 is an inhibitor of monopolar spindle 1 (Mps1; IC50 = 0.63 nM). It is selective for Mps1 over a panel of kinases at 10 nM. BAY 12-17389 promotes cell-cycle progression into mitosis in metaphase-arrested HeLa cells (IC50 = 11 nM). BAY 12-17389 (1.5 mg/kg) enhances paclitaxel-induced inhibition of tumor growth in a SUM149 triple-negative breast cancer (TNBC) mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-cyclopropyl
CAS Number
1554458-53-5
Molecular Formula
C27H24F5N5O3
Formula Weight
561.5
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 25 mg/mL
- DMF:PBS (pH 7.2)(1:3): 0.25 mg/mL
- DMSO: 15 mg/mL
λmax
271, 304 nm
SMILES
COC1=C(F)C(F)=C(OC2=NN3C(C(NCCC(F)(F)F)=C2)=NC=C3C4=CC(C)=C(C(NC5CC5)=O)C=C4)C=C1
InChi Code
InChI=1S/C27H24F5N5O3/c1-14-11-15(3-6-17(14)26(38)35-16-4-5-16)19-13-34-25-18(33-10-9-27(30,31)32)12-22(36-37(19)25)40-21-8-7-20(39-2)23(28)24(21)29/h3,6-8,11-13,16,33H,4-5,9-10H2,1-2H3,(H,35,38)
InChi Key
WNEILUNVMHVMPH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21660-1 |
|---|---|
| Supplier Part Number | 21660-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1554458-53-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |