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Cayman DG-051
List Price $268.00 Your Price $268.00
Cayman DG-051 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-21688-10
MFG.PART: 21688-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
DG-051 is a potent, orally bioavailable leukotriene A4 hydrolase (LTA4H) inhibitor (Kd = 25 nM; IC50 = 47 nM), the enzyme that catalyzes the rate-determining step in the synthesis of LTB4 (Item No. 20110).1 However, it also inhibits the aminopeptidase activity of LTA4H with IC50 values of 72 and 150 nM when tested using the substrates L-alanine p-nitroanaline and prolyl-glycyl-proline peptide (PGP; Item No. 11188), respectively, potentially leading to PGP accumulation in vivo.1,2 DG-051 does not show any inhibitory activity against a panel of more than 50 additional aminopeptidases, ion channels, or HERG.1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(2S)-2-[[4-(4-
CAS Number
929915-58-2
Molecular Formula
C21H24ClNO4 • HCl
Formula Weight
426.3
Purity
≥98%
Formulation(Request formulation change)
A solution in ethanol
Solubility(Learn about Variance in Solubility)
- DMF: 20 mg/mL
- DMSO: 12.5 mg/mL
- Ethanol: 12.5 mg/mL
- PBS (pH 7.2): 2 mg/mL
λmax
231, 279 nm
SMILES
ClC1=CC=C(OC2=CC=C(OC[C@@H]3CCCN3CCCC(O)=O)C=C2)C=C1.Cl
InChi Code
InChI=1S/C21H24ClNO4.ClH/c22-16-5-7-19(8-6-16)27-20-11-9-18(10-12-20)26-15-17-3-1-13-23(17)14-2-4-21(24)25;/h5-12,17H,1-4,13-15H2,(H,24,25);1H/t17-;/m0./s1
InChi Key
UCPVOTSNNAVKNE-LMOVPXPDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-21688-10 |
|---|---|
| Supplier Part Number | 21688-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 929915-58-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |