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Cayman Mycophenolic Acid
List Price $82.00 Your Price $82.00
Cayman Mycophenolic Acid - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-21716-100
MFG.PART: 21716-100
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Mycophenolic acid is an immunosuppresive microbial metabolite that has been found in P. brevicompactum., It is also an active metabolite of mycophenolate mofetil (Item No. ) that is formed via carboxylesterase 1 (CES1) and CES2. Mycophenolic acid is an inhibitor of IMP dehydrogenase (IMPDH) type I and type II (IC50s = 32 and 11 nM, respectively, in cell-free assays) and inhibits DNA synthesis in L strain mouse fibroblasts when used at concentrations ranging from 0.1 to 10 µg/mL., It is active against several strains of C. albicans, C. parakrusei, C. tropicalis, and C. neoformans (MICs = 3.9-31.25 µg/mL), as well as various strains of S. aureus (MICs = 31.25-125 µg/mL). Mycophenolic acid (150 mg/kg) reduces splenomegaly in a mouse model of Friend virus-induced leukemia. It decreases the number of hemolytic plaque forming cells isolated from the spleen of mice immunized with sheep red blood cells (RBCs) when administered at doses ranging from 60 to 240 mg/kg. Formulations containing mycophenolic acid have been used as immunosuppressive agents in the prevention of organ transplant rejection.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(4E)-6-(1,3-
CAS Number
24280-93-1
Synonyms
- MPA
- NSC 129185
Molecular Formula
C17H20O6
Formula Weight
320.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 5 mg/mL
- DMSO: 10 mg/mL
- PBS (pH 7.2): 10 mg/mL
λmax
215, 249, 305 nm
SMILES
O=C1OCC2=C1C(O)=C(C/C=C(C)/CCC(O)=O)C(OC)=C2C
InChi Code
InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
InChi Key
HPNSFSBZBAHARI-RUDMXATFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21716-100 |
|---|---|
| Supplier Part Number | 21716-100 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Australia |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 24280-93-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |