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Cayman C527
List Price
$158.00
Your Price
$158.00
Cayman C527 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-21771-10
MFG.PART:
21771-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
C527 is an inhibitor of USP1/UAF complex deubiquitinase activity (IC50 = 0.88 µM). It also inhibits USP5, UCL-H3, and USP12/46 but not UCL-H1 activity (IC50s = 1.65, 2.18, 5.97, and >10 µM, respectively). C527 increases ubiquinated Fanconi anemia complementation group D2 (FANCD2-Ub) and FANCI-Ub levels in a concentration-dependent manner. It inhibits homologous recombination repair, cell proliferation, and sensitizes HeLa cells to the DNA crosslinker mitomycin C (Item No. ). C527 also inhibits proliferation of PC3 and LNCap prostate cancer cells (IC50s = 0.24 and 0.03 µM, respectively, after 72 hours).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-(4-fluoro
CAS Number
192718-06-2
Molecular Formula
C17H8FNO3
Formula Weight
293.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 0.33 mg/mL
- DMSO: 0.16 mg/mL
λmax
277 nm
SMILES
O=C(C(OC(C1=CC=C(F)C=C1)=N2)=C2C3=O)C4=C3C=CC=C4
InChi Code
InChI=1S/C17H8FNO3/C18-10-7-5-9(6-8-10)17-19-13-14(20)11-3-1-2-4-12(11)15(21)16(13)22-17/h1-8H
InChi Key
ULJDFEYQOPCCPM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21771-10 |
|---|---|
| Supplier Part Number | 21771-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 192718-06-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |