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Cayman MK-0812
List Price
$81.00
Your Price
$81.00
Cayman MK-0812 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-21803-1
MFG.PART:
21803-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
MK-0812 is an antagonist of chemokine (C-C) motif receptor 2 (CCR2; IC50 = 5 nM for the human receptor). It inhibits mammosphere formation of BT-549 breast cancer cells, an effect that is enhanced by the β-catenin inhibitor PNU 74654 (Item No. ). MK-0812 (0.03, 0.1, and 0.3 mg/kg) increases chemokine (C-C) motif ligand 2 (CCL2) levels and decreases CD11b+ monocytes in mouse blood.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1,5-anhydro-
CAS Number
624733-88-6
Molecular Formula
C24H34F3N3O3
Formula Weight
469.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 15 mg/mL
- DMF:PBS (pH 7.2) (1:20): 0.04 mg/mL
- DMSO: 1 mg/mL
- Ethanol: 10 mg/mL
λmax
267 nm
SMILES
O=C([C@@]1(C(C)C)CC[C@@H](N[C@]2([H])[C@H](OC)COCC2)C1)N(C3)CCC4=C3C=C(C(F)(F)F)C=N4
InChi Code
InChI=1S/C24H34F3N3O3/c1-15(2)23(7-4-18(11-23)29-20-6-9-33-14-21(20)32-3)22(31)30-8-5-19-16(13-30)10-17(12-28-19)24(25,26)27/h10,12,15,18,20-21,29H,4-9,11,13-14H2,1-3H3/t18-,20+,21-,23+/m1/s1
InChi Key
MTMDXAIUENDNDL-RJSMDTJLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21803-1 |
|---|---|
| Supplier Part Number | 21803-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 624733-88-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |