Cayman NFAT Activation Inhibitor III

NFAT activation inhibitor III is a cell-permeant inhibitor of signaling through nuclear factor of activated T cells (NFAT).¹ It binds the substrate recognition site of the phosphatase calcineurin (K_d = 0.8 µM), preventing it from binding and dephosphorylating NFAT.¹ NFAT activation inhibitor III blocks the nuclear import of NFAT in T cells stimulated with ionomycin (Item No. 10004974). It prevents the induced expression of cytokine mRNAs in T cells stimulated with phorbol ester and ionomycin.¹

WARNING This product is not for human or veterinary use.