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Cayman Grazoprevir
List Price
$102.00
Your Price
$102.00
Cayman Grazoprevir - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-21816-10
MFG.PART:
21816-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Grazoprevir is a pan-genotypic protease inhibitor that binds to hepatitis C virus (HCV) non-structural protein 3/4A (NS3/4A), a serine protease essential for viral replication. Grazoprevir has potent in vitro activity against major HCV genotypes (Kis = 0.1, 0.1, 0.08, 0.15, and 0.9 nM for genotypes 1a, 1b, 2a, 2b, and 3a, respectively) and common resistance genotypes (Kis = 0.07, 0.14, and 0.30 nM for genotypes 1b R155K, D165V, and D168Y, respectively). Grazoprevir inhibits the NS3/4A protease in an in vitro replicon system with EC50 values of 2 and 8 nM for genotypes 1a and 2a, respectively. Formulations containing grazoprevir are used in combination therapies to treat HCV.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(1R,2S)-N-
CAS Number
1350514-68-9
Synonyms
- MK-5172
Molecular Formula
C38H50N6O9S
Formula Weight
766.9
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMF:PBS (pH 7.2) (1:4): 0.2 mg/mL
- DMSO: 25 mg/mL
- Ethanol: 15 mg/mL
λmax
215, 253, 342 nm
SMILES
COC1=CC=C2C(N=C(O[C@]3([H])C[C@@H](C(N[C@]4(C[C@@H]4C=C)C(NS(C5CC5)(=O)=O)=O)=O)N6C3)C(CCCCC[C@@](C7)([H])[C@]7([H])OC(N[C@H](C6=O)C(C)(C)C)=O)=N2)=C1
InChi Code
InChI=1S/C38H50N6O9S/c1-6-22-19-38(22,35(47)43-54(49,50)25-13-14-25)42-32(45)29-18-24-20-44(29)34(46)31(37(2,3)4)41-36(48)53-30-16-21(30)10-8-7-9-11-27-33(52-24)40-28-17-23(51-5)12-15-26(28)39-27/h6,12,15,17,21-22,24-25,29-31H,1,7-11,13-14,16,18-20H2,2-5H3,(H,41,48)(H,42,45)(H,43,47)/t21-,22+,24-,29+,30-,31-,38+/m1/s1
InChi Key
OBMNJSNZOWALQB-SXYDHYGOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21816-10 |
|---|---|
| Supplier Part Number | 21816-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1350514-68-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |