Cayman P1075

P1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-K_IR6) with an EC₅₀ value of 45 nM for SUR2B-K_IR6 channel activation.¹ It is highly selective for SUR2 over SUR1 isoforms (IC₅₀s = 9-46 nM and 1.02 mm, respectively, in a radioligand binding assay). P1075 increases outflow facility, a marker of reduced intraocular pressure, in human eye anterior segments ex vivo.² It also reduces infarct size in isolated rabbit hearts via activation of mitochondrial ATP-sensitive potassium channels (K_ATP; EC₅₀s = 60-90 nM).³

WARNING This product is not for human or veterinary use.