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Cayman ARRY-520
List Price $36.00 Your Price $36.00
Cayman ARRY-520 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-21883-1
MFG.PART: 21883-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
ARRY-520 is a potent inhibitor of the kinesin spindle protein Eg5 (IC50 = 6 nM). It is selective for Eg5 over a panel of 8 kinesins (IC50s = >100 μM) and a panel of 224 kinases at a concentration of 10 μM. ARRY-520 induces time-and dose-dependent cell death in HL-60, Jurkat, OCI-AML3, U937, and MOLM-13 leukemic cells. Downregulation of Eg5 expression sensitizes HL-60 cells to ARRY-520 (IC50s = 11.3 and 2 nM for wild-type and Eg5 knockdown HL-60 cells, respectively). ARRY-520 induces cell cycle arrest at the g2/M phase in a p53- and XIAP-independent manner in OCI-AML3 cells. It also inhibits blast colony formation of bone marrow samples derived from human acute myeloid leukemia (AML) patients. In vivo, ARRY-520 (20 mg/kg per day) completely eliminates tumors in the RPMI-8226 multiple myeloma and HL-60 and MV4-11 AML mouse xenograft models.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(2S)-2-(3-amino
CAS Number
885060-09-3
Synonyms
- Filanesib
Molecular Formula
C20H22F2N4O2S
Formula Weight
420.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/mL
- DMSO: 20 mg/mL
- Ethanol: 20 mg/mL
- PBS (pH 7.2): 0.2 mg/mL
λmax
231, 332 nm
SMILES
O=C(N(C)OC)N1[C@@](C2=CC=CC=C2)(CCCN)SC(C3=C(F)C=CC(F)=C3)=N1.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C20H22F2N4O2S.C2HF3O2/c1-25(28-2)19(27)26-20(11-6-12-23,14-7-4-3-5-8-14)29-18(24-26)16-13-15(21)9-10-17(16)22;3-2(4,5)1(6)7/h3-5,7-10,13H,6,11-12,23H2,1-2H3;(H,6,7)/t20-;/m0./s1
InChi Key
CIJUJPVFECBUKG-BDQAORGHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21883-1 |
|---|---|
| Supplier Part Number | 21883-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 885060-09-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |