Cayman CCR4 Antagonist (hydrochloride)

Chemokine (C-C motif) receptor 4 (CCR4) antagonist is an antagonist of CCR4. It inhibits activation of CCR4 by chemokine (C-C motif) ligand 22 (CCL22) in a [³⁵S]GTPγS assay and also inhibits chemotaxis in human and mouse CCR4-expressing B300-19 cells (IC₅₀s = 18, 140, and 39 nM, respectively). CCR4 antagonist inhibits microglial activation in the cortex in a mouse model of hepatic encephalopathy induced by the neurotoxin azoxymethane when administered at a dose of 1 mg/kg per day. It reduces azoxymethane-induced increases in Il6 and Il1b expression in mouse cortex. CCR4 antagonist reduces mechanical and thermal sensitivity in a mouse model of type I diabetes induced by streptozotocin (Item No. ) when administered intrathecally at doses ranging from 10 to 30 µg/animal.

WARNING This product is not for human or veterinary use.