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Cayman GRI-977143
List Price $40.00 Your Price $40.00
Cayman GRI-977143 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-21900-1
MFG.PART: 21900-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
GRI-977143 is an agonist of g protein-coupled lysophosphatidic acid receptor 2 (LPA2) with an EC50 value of 3.3 μM in LPA2-transfected RH7777 cells. It is selective for LPA2, having no activity at LPA1, LPA3, LPA4, and LPA5 at concentrations up to 10 μM. GRI-977143 increases growth and reduces caspase-3 and -7 activation in LPA2-transduced MEF fibroblasts. It increases MM1 rat hepatoma cell invasion and inhibits apoptosis of IEC-6 cells induced by TNF-α, doxorubicin (Item No. ), or serum withdrawal. GRI-977143 also rescues apoptotic cells from γ-irradiation-induced injury in vitro and in vivo.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[[3-(1,3-
CAS Number
325850-81-5
Molecular Formula
C22H17NO4S
Formula Weight
391.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/mL
- DMSO: 10 mg/mL
- DMSO:PBS (pH 7.2) (1:40): 0.025 mg/mL
λmax
232 nm
SMILES
O=C(O)C1=CC=CC=C1SCCCN2C(C3=C4C(C2=O)=CC=CC4=CC=C3)=O
InChi Code
InChI=1S/C22H17NO4S/c24-20-16-9-3-6-14-7-4-10-17(19(14)16)21(25)23(20)12-5-13-28-18-11-2-1-8-15(18)22(26)27/h1-4,6-11H,5,12-13H2,(H,26,27)
InChi Key
GMVZUCHUOYUMLL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21900-1 |
|---|---|
| Supplier Part Number | 21900-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 325850-81-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |