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Cayman BC-1215
List Price
$44.00
Your Price
$44.00
Cayman BC-1215 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-21964-1
MFG.PART:
21964-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
BC-1215 is an inhibitor of F-box protein 3 (FBXO3; IC50 = 0.9 μg/mL for Il-1β release). It decreases FBXO3 interaction with F-box/LRR-repeat protein 2 (FBXL2) in a dose-dependent manner and prevents FBXO3-dependent ubiquitination of FBXL2. It also lowers expression of Tnf receptor-associated factors (TRAFs) 1-6 without affecting TRAF1-6 mRNA levels in resting and LPS-stimulated peripheral blood mononuclear cells (PBMCs). BC-1215 (100 μg, i.p., per animal) reduces plasma levels of the inflammatory cytokines Il-6, Tnf, and Il-1β and decreases peritoneal bacteria counts in a mouse model of cecal ligation and puncture-induced sepsis. It also reduces inflammation in mouse models of DSS-induced colitis, paw edema, and ear edema.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N1,N2-bis[[4-
CAS Number
1507370-20-8
Molecular Formula
C26H26N4
Formula Weight
394.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 0.5 mg/mL
λmax
250, 280 nm
SMILES
C1(C2=CC=C(CNCCNCC3=CC=C(C4=CC=CC=N4)C=C3)C=C2)=CC=CC=N1
InChi Code
InChI=1S/C26H26N4/c1-3-15-29-25(5-1)23-11-7-21(8-12-23)19-27-17-18-28-20-22-9-13-24(14-10-22)26-6-2-4-16-30-26/h1-16,27-28H,17-20H2
InChi Key
IXEPQJQQSLMESJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21964-1 |
|---|---|
| Supplier Part Number | 21964-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1507370-20-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |