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Cayman Ponesimod
List Price
$42.00
Your Price
$42.00
Cayman Ponesimod - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-22053-1
MFG.PART:
22053-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Ponesimod is a potent agonist of sphingosine-1-phosphate receptor 1 (S1P1/EDG-1; IC50s = 6, >10,000, 2,068, 1,956, and 142 nM for S1P1-S1P5, respectively, in a radioligand binding assay). It selectively activates S1P1 in a GTPγS assay (EC50s = 5.7, >10,000, 105, 1,108, and 59.1 nM, for S1P1-S1P5, respectively). Ponesimod (3-100 mg/kg) reduces the number of circulating lymphocytes in rats in a dose-dependent manner. It reduces edema, protein extravasation, neutrophil activity, and skin levels of the proinflammatory cytokines IL-1β, IL-6, IFN-γ, and TNF-α in a mouse model of delayed-type hypersensitivity at a dose of 30 mg/kg. Ponesimod (30 mg/kg) also prevents footpad swelling in a rat model of adjuvant-induced arthritis.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(2Z)-5Z-[[3-
CAS Number
854107-55-4
Molecular Formula
C23H25ClN2O4S
Formula Weight
461.0
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 5 mg/mL
- DMSO: 5 mg/mL
- DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL
λmax
242, 345 nm
SMILES
ClC1=CC(/C=C(C(N/2C3=C(C)C=CC=C3)=O)\SC2=N/CCC)=CC=C1OC[C@H](O)CO
InChi Code
InChI=1S/C23H25ClN2O4S/c1-3-10-25-23-26(19-7-5-4-6-15(19)2)22(29)21(31-23)12-16-8-9-20(18(24)11-16)30-14-17(28)13-27/h4-9,11-12,17,27-28H,3,10,13-14H2,1-2H3/b21-12-,25-23-/t17-/m1/s1
InChi Key
LPAUOXUZGSBGDU-STDDISTJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-22053-1 |
|---|---|
| Supplier Part Number | 22053-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 854107-55-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |