We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman Ketanserin (tartrate)
List Price $76.00 Your Price $76.00
Cayman Ketanserin (tartrate) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-22058-100
MFG.PART: 22058-100
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Ketanserin is a potent antagonist of the serotonin (5-HT) receptor that is selective for 5-HT2 (IC50 = 6.3 nM; Ki = 2.1 nM). It has no activity at 5-HT1 receptors but does have activity at histamine type 1, α1-adrenergic, and dopamine receptors with Ki values of 10, 10, and 220 nM, respectively. Ketanserin induces dose-dependent inhibition of contractile responses to 5-HT in isolated rat caudal artery, canine basilar, carotid, coronary and gastrosplenic arteries, and canine gastrosplenic and saphenous veins. Ketanserin (10 mg/kg/day) significantly decreases blood pressure (BP), blood pressure variability (BPV), and hypertensive organ damage in spontaneously hypertensive rats. Formulations containing ketanserin have been used to treat hypertension in early-onset preeclampsia.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3-[2-[4-(4-
CAS Number
83846-83-7
Molecular Formula
C22H22FN3O3 • C4H6O6
Formula Weight
545.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 25 mg/mL
- DMSO: 25 mg/mL
- DMSO:PBS (pH 7.2)(1:9): 0.1 mg/mL
λmax
219, 244 nm
SMILES
O=C1N(CCN2CCC(C(C3=CC=C(F)C=C3)=O)CC2)C(C4=CC=CC=C4N1)=O.OC([C@H](O)[C@@H](O)C(O)=O)=O
InChi Code
InChI=1S/C22H22FN3O3.C4H6O6/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29;5-1(3(7)8)2(6)4(9)10/h1-8,16H,9-14H2,(H,24,29);1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/M.1/s1
InChi Key
KMTLTEVOQLMYRS-LREBCSMRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-22058-100 |
|---|---|
| Supplier Part Number | 22058-100 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 83846-83-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |