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Cayman LM22A-4
List Price $525.00 Your Price $525.00
Cayman LM22A-4 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-22082-50
MFG.PART: 22082-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
LM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (TrkB; IC50 = 47 nM in a fluorescence anisotropy assay).1 It selectively inhibits BDNF binding to 3T3 cells expressing TrkB over those expressing TrkA, TrkC, or p75NTR. In vitro, LM22A-4 increases survival of hippocampal neurons via activation of TrkB as well as Akt and ERK downstream pro-survival signaling pathways. In vivo, LM22A-4 increases dwell time in an accelerating rotarod task, indicating improved motor learning in a rat model of traumatic brain injury. LM22A-4 restores TrkB phosphorylation in the medulla and pons and breathing frequency to wild-type levels in a mouse model of Rett syndrome when administered at a dose of 50 mg/kg.2 It reduces neurite degeneration, formation of intranuclear huntingtin aggregates, and improves downward climbing and grip strength in mouse models of Huntingtons disease.3 LM22A-4 (0.22 mg/kg) also improves limb swing speed and accelerates return to normal gait accuracy in a mouse model of hypoxic-ischemic stroke.4
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N1,N3,N5-Tris
CAS Number
37988-18-4
Molecular Formula
C15H21N3O6
Formula Weight
339.3
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 10 mg/mL
- DMSO: 30 mg/mL
- PBS (pH 7.2): 10 mg/mL
SMILES
O=C(NCCO)C1=CC(C(NCCO)=O)=CC(C(NCCO)=O)=C1
InChi Code
InChI=1S/C15H21N3O6/c19-4-1-16-13(22)10-7-11(14(23)17-2-5-20)9-12(8-10)15(24)18-3-6-21/h7-9,19-21H,1-6H2,(H,16,22)(H,17,23)(H,18,24)
InChi Key
RGWJKANXFYJKHN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-22082-50 |
|---|---|
| Supplier Part Number | 22082-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 37988-18-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |