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Cayman XMU-MP-1
List Price $28.00 Your Price $28.00
Cayman XMU-MP-1 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-22083-1
MFG.PART: 22083-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
XMU-MP-1 is an inhibitor of the pro-apoptotic, sterile 20-like kinases MST1 and 2 (IC50s = 71.1 and 38.1 nM, respectively). It is selective for MST1 and 2 over a panel of 468 kinases at a concentration of 1 μM. XMU-MP-1 inhibits phosphorylation of MOB1, LATS1 and 2, and YAP in HepG2 cells as well as MST1 and 2 autophosphorylation in RAW 264.7, U2OS, SW480, RPE1, SNU423, and HepG2 cells in a concentration-dependent manner. It also prevents cell death induced by overexpression of MST2. XMU-MP-1 (1 mg/kg) enhances liver regeneration in mice post partial hepatectomy and reduces liver fibrosis in a mouse model of chronic liver injury.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[(6,10-di
CAS Number
2061980-01-4
Molecular Formula
C17H16N6O3S2
Formula Weight
416.5
Purity
≥98%
Formulation
A solid
Solubility
- DMF: 2 mg/mL
- Ethanol: 500 µg/mL
λmax
299 nm
SMILES
O=C(N1C)C2=C(C=CS2)N(C)C3=C1C=NC(NC4=CC=C(S(N)(=O)=O)C=C4)=N3
InChi Code
InChI=1S/C17H16N6O3S2/c1-22-12-7-8-27-14(12)16(24)23(2)13-9-19-17(21-15(13)22)20-10-3-5-11(6-4-10)28(18,25)26/h3-9H,1-2H3,(H2,18,25,26)(H,19,20,21)
InChi Key
YRDHKIFCGOZTGD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-22083-1 |
|---|---|
| Supplier Part Number | 22083-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2061980-01-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |