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Cayman 4μ8C
List Price $128.00 Your Price $128.00
Cayman 4μ8C - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-22110-25
MFG.PART: 22110-25
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
4µ8C is an inhibitor of inositol requiring enzyme 1 α (IRE1α), which is a protein located in the endoplasmic reticulum (ER) membrane that has kinase and RNase activities triggered by ER stress.1 4µ8C inhibits IRE1α splicing of Xbp1 mRNA (IC50 = 6.8 µM) and reduces subsequent gene expression of Erdj4 (IC50 = 3.4 µM) in stress-cultured MEF cells but does not block IRE1α autophosphorylation. It reduces IL-4 production in CD4+ T cells isolated from murine spleen and LPS-stimulated increases in TNF-α and IL-6 mRNA expression and protein secretion in isolated alveolar macrophages from patients with cystic fibrosis.2,3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
7-hydroxy-4-
CAS Number
14003-96-4
Synonyms
- IRE1 Inhibitor III
Molecular Formula
C11H8O4
Formula Weight
204.2
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMF:PBS (pH 7.2) (1:8): 0.1 mg/mL
- DMSO: 25 mg/mL
- Ethanol: 10 mg/mL
λmax
274 nm
SMILES
OC1=CC=C(C(C)=CC(O2)=O)C2=C1C=O
InChi Code
InChI=1S/C11H8O4/c1-6-4-10(14)15-11-7(6)2-3-9(13)8(11)5-12/h2-5,13H,1H3
InChi Key
RTHHSXOVIJWFQP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-22110-25 |
|---|---|
| Supplier Part Number | 22110-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 14003-96-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |