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Cayman PF-01247324
List Price
$37.00
Your Price
$37.00
Cayman PF-01247324 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-22111-1
MFG.PART:
22111-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
PF-01247324 is a blocker of the tetrodotoxin-resistant (TTX-R) sodium channel Nav1.8 (IC50 = 0.19 μM for human Nav1.8). It is selective for Nav1.8 over Nav1.1, Nav1.2, Nav1.5, and Nav1.7 channels (IC50s = 13, 12.8, 9, and 19 μM, respectively) as well as ether-a-go-go (ERG) potassium channels (IC50 = 30 μM). PF-01247324 blocks Nav1.8 channels in a VSP-FRET assay using HEK293 cells (IC50 = 2.6 μM). In vivo, PF-01247324 (100 mg/kg) reduces phase 2 flinching in a rat model of formalin-induced persistent pain. It increases latency to lift the inflamed paw and latency to paw withdrawal in rat models of carrageenan-induced thermal hyperalgesia and mechanical hyperalgesia induced by complete Freunds adjuvant (CFA), respectively.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-amino-N-
CAS Number
875051-72-2
Molecular Formula
C13H10Cl3N3O
Formula Weight
330.6
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 30 mg/mL
- Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/mL
λmax
329 nm
SMILES
ClC1=CC(Cl)=CC(C2=C(N)N=C(C(NC)=O)C=C2)=C1Cl
InChi Code
InChI=1S/C13H10Cl3N3O/c1-18-13(20)10-3-2-7(12(17)19-10)8-4-6(14)5-9(15)11(8)16/h2-5H,1H3,(H2,17,19)(H,18,20)
InChi Key
HPIUHDCRVYDAEJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-22111-1 |
|---|---|
| Supplier Part Number | 22111-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 875051-72-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |