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Cayman APS-2-79 (hydrochloride)
List Price
$37.00
Your Price
$37.00
Cayman APS-2-79 (hydrochloride) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-22137-1
MFG.PART:
22137-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
APS-2-79 is an inhibitor of MAPK signaling dependent on kinase suppressor of Ras (KSR). It inhibits ATPbiotin binding to KSR2 in KSR2-MEK1 complexes (IC50 = 120 nM), stabilizes KSR2 in an inactive state, and reduces interactions between B-RAF and KSR2-MEK1 complexes., APS-2-79 (5 μM) inhibits KSR-stimulated phosphorylation of MEK and ERK in HEK293H cells. It enhances the efficacy of the MEK inhibitor trametinib (Item No. ), further reducing cell viability in HCT116 and A549 cell lines containing K-Ras mutations, but not B-RAF mutant SK-MEL-239 and A375 cell lines, when used at a concentration of 1 μM.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6,7-dimethoxy
CAS Number
2002381-31-7
Molecular Formula
C23H21N3O3 • HCl
Formula Weight
423.9
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/mL
- DMSO: 25 mg/mL
- DMSO:PBS (pH 7.2) (1:2): 0.3 mg/mL
- Ethanol: 1 mg/mL
λmax
220, 252, 342 nm
SMILES
COC1=C(OC)C=C(C(NC2=C(C)C=C(OC3=CC=CC=C3)C=C2)=NC=N4)C4=C1.Cl
InChi Code
InChI=1S/C23H21N3O3.ClH/c1-15-11-17(29-16-7-5-4-6-8-16)9-10-19(15)26-23-18-12-21(27-2)22(28-3)13-20(18)24-14-25-23;/h4-14H,1-3H3,(H,24,25,26);1H
InChi Key
LIXKSHWZJNNZHG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-22137-1 |
|---|---|
| Supplier Part Number | 22137-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2002381-31-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |