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Cayman SB-742457
List Price $775.00 Your Price $775.00
Cayman SB-742457 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-22200-25
MFG.PART: 22200-25
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
SB-742457 is an orally bioavailable antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 1.4 nM).1,2 SB-742457 (1 μM) also binds to 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors with high affinity.3 SB-742457 reduces 5-HT6 activation of gs-mediated cAMP production in a concentration-dependent manner with an EC50 value of 21 nM in NG108-15 neuroblastoma cells.2 In vivo, SB-742457 (1.5 mg/kg, p.o.) reverses deficits in novel object recognition induced by scopolamine (Item No. 14108) in rats.1 It also reverses age-induced impairments in spatial memory acquisition and retention in rats in the Morris water maze. SB-742457 (3.0 mg/kg, i.p.) reduces the number of licking bouts by 24% compared with control in rats trained to lick a glucose solution, indicating a role in satiety and obesity management.4
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3-(phenyl
CAS Number
607742-69-8
Synonyms
- GSK742457
Molecular Formula
C19H19N3O2S
Formula Weight
353.4
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 5 mg/mL
- DMSO: 5 mg/mL
- Ethanol: 0.1 mg/mL
λmax
273, 364 nm
SMILES
O=S(C(C=N1)=CC2=C1C(N3CCNCC3)=CC=C2)(C4=CC=CC=C4)=O
InChi Code
InChI=1S/C19H19N3O2S/c23-25(24,16-6-2-1-3-7-16)17-13-15-5-4-8-18(19(15)21-14-17)22-11-9-20-10-12-22/h1-8,13-14,20H,9-12H2
InChi Key
JJZFWROHYSMCMU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-22200-25 |
|---|---|
| Supplier Part Number | 22200-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 607742-69-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |