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Cayman Sch 442416; Purity- Greater Than Or Equal To 98%; Size- 10
List Price
$214.00
Your Price
$214.00
Cayman Sch 442416; Purity- Greater Than Or Equal To 98%; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-22233-10
MFG.PART:
22233-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. α-Naphthoflavone is a flavone that modulates xenobiotic metabolism at several points. It antagonizes AhR, blocking the expression of phase I and II genes at nanomolar concentrations, although it can agonize AhR at higher concentrations (10 µM)., α-Naphthoflavone inhibits CYP19 (aromatase), CYP1A1, CYP1A2, and CYP1B1 (IC50s = 500, 60, 6, and 5 nM, respectively), whereas it activates CYP3A4 (Kd = 7.4 µM).,, Dietary α-naphthoflavone can contribute to carcinogenesis in the presence of synthetic estrogens.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-phenyl-4H-
CAS Number
604-59-1
Synonyms
- 7,8-Benzoflavone
- NSC 407011
Molecular Formula
C19H12O2
Formula Weight
272.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/ml
- DMF:PBS (pH 7.2) (1:4): 0.1 mg/ml
- DMSO: 10 mg/ml
- Ethanol: 1 mg/ml
λmax
225, 280, 344 nm
SMILES
O=C1C2=C(C(C=CC=C3)=C3C=C2)OC(C4=CC=CC=C4)=C1
InChi Code
InChI=1S/C19H12O2/c20-17-12-18(14-7-2-1-3-8-14)21-19-15-9-5-4-6-13(15)10-11-16(17)19/h1-12H
InChi Key
VFMMPHCGEFXGIP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-22233-10 |
|---|---|
| Featured | No |
| Supplier Part Number | 22233-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 316173-57-6 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |