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Cayman SCH 442416
List Price $544.00 Your Price $544.00
Cayman SCH 442416 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-22233-25
MFG.PART: 22233-25
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
SCH 442416 is a potent, brain-permeable, and selective adenosine A2A receptor (A2AR) antagonist.1 It is selective for A2AR with a Ki value of 0.048 nM compared to 1,111, >10,000, and >10,000 nM for A1R, A2BR, and A3R, respectively, using human recombinant protein in a radioligand binding assay. It is also selective for A2AR (Ki = 0.50 nM) in rat cerebral membranes over A1R and A3R (Kis = 1,815 and >10,000, respectively). Biodistribution in rats demonstrates preferential uptake by liver, adrenal gland, kidney, and lungs, and by the striatum in the brain. SCH 442416 (10 μM) attenuates adenosine-mediated and A2AR agonist-induced arteriole dilation.2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-(2-furanyl)
CAS Number
316173-57-6
Molecular Formula
C20H19N7O2
Formula Weight
389.4
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 15 mg/mL
- DMF:PBS(pH7.2) (1:2): 0.33 mg/mL
- DMSO: 10 mg/mL
λmax
216, 229, 263 nm
SMILES
NC1=NC2=C(C=NN2CCCC3=CC=C(OC)C=C3)C4=NC(C5=CC=CO5)=NN14
InChi Code
InChI=1S/C20H19N7O2/c1-28-14-8-6-13(7-9-14)4-2-10-26-18-15(12-22-26)19-23-17(16-5-3-11-29-16)25-27(19)20(21)24-18/h3,5-9,11-12H,2,4,10H2,1H3,(H2,21,24)
InChi Key
AEULVFLPCJOBCE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-22233-25 |
|---|---|
| Supplier Part Number | 22233-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 316173-57-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |