Cayman 2’2’-cGAMP (sodium salt)

2’2’-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 25-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes (STING; Item Nos. | ), which is a component of the innate immune response that activates the type I interferon pathway when bound to cyclic dinucleotides. 2’2-cGAMP shows weaker binding to STING than 2’3’-cGAMP (Item No. ; K_d = 287 and 3.79 nM, respectively) but binds more strongly than 3’3’-cGAMP (Item No. ), cyclic di-GMP (Item No. ), or 3’2’-cGAMP, which bind in the micromolar range (K_ds = 1.04, 1.21, or 1.61 µM, respectively). Despite weaker binding, 2’2’-cGAMP induces IFN-β production in the same concentration range as 2’3’-cGAMP (EC₅₀s = 15.8 and 19.4 nM, respectively, in L929 cells).

WARNING This product is not for human or veterinary use.