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Cayman LCL-161
List Price $956.00 Your Price $956.00
Cayman LCL-161 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-22420-50
MFG.PART: 22420-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
LCL-161 is a small molecule Smac mimetic that inhibits multiple inhibitor of apoptosis (IAP) family proteins.1 As a single agent, LCL-161 inhibits growth of FLT3-ITD-expressing leukemia cells via induction of apoptosis with IC50 values ranging from 0.5-4 μM. In vivo, LCL-161 enhances growth inhibition driven by PKC 412 (Item No. 10459) in a mouse Ba/F3-FLT3-ITD-luc+ leukemia xenograft model. It exhibits additive effects with the chemotherapeutic agents doxorubicin (Item No. 15007) and cytarabine (Item No. 16069). LCL-161 also inhibits growth of nilotinib-resistant leukemia cell lines and exhibits synergy with nilotinib (Item No. 10010422) in a Bcr-Abl expressing, 32D.p20-luc+ leukemia mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[(1S)-1-
CAS Number
1005342-46-0
Synonyms
- NVP-LCL161
Molecular Formula
C26H33FN4O3S
Formula Weight
500.6
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 20 mg/mL
- Ethanol: 20 mg/mL
λmax
271 nm
SMILES
O=C(N1CCC[C@H]1C2=NC(C(C3=CC=C(F)C=C3)=O)=CS2)[C@@H](NC([C@@H](NC)C)=O)C4CCCCC4
InChi Code
InChI=1S/C26H33FN4O3S/c1-16(28-2)24(33)30-22(17-7-4-3-5-8-17)26(34)31-14-6-9-21(31)25-29-20(15-35-25)23(32)18-10-12-19(27)13-11-18/h10-13,15-17,21-22,28H,3-9,14H2,1-2H3,(H,30,33)/t16-,21-,22-/m0/s1
InChi Key
UFPFGVNKHCLJJO-SSKFGXFMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-22420-50 |
|---|---|
| Supplier Part Number | 22420-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1005342-46-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |