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Cayman Tpi-1; Purity- Greater Than Or Equal To 95%; Size- 1 Mg
List Price
$37.00
Your Price
$37.00
Cayman Tpi-1; Purity- Greater Than Or Equal To 95%; Size- 1 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-22480-1
MFG.PART:
22480-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
TPI-1 is an inhibitor of protein tyrosine phosphatases. TPI-1 (10 ng/ml) increases phosphorylated substrates of the phosphatase SHP-1 in Jurkat T cells, including pLck-pY394, pZap70, and pSlp76. It is selective for SHP-1 over SHP-2, having low activity at the SHP-2 substrate pERK1/2. It increases pLck-pY394 levels by approximately 3.3-fold and increases the number of IFN-γ+ cells in mouse spleen ex vivo following a dose of approximately 3 mg/kg. Oral administration of TPI-1 (3 mg/kg per day) inhibits tumor growth in a B16 melanoma mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-(2,5-
CAS Number
79756-69-7
Synonyms
- Tyrosine Phosphatase Inhibitor 1
Molecular Formula
C12H6Cl2O2
Formula Weight
253.1
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- Ethanol: 1 mg/ml
λmax
229 nm
SMILES
ClC1=C(C(C(C=C2)=O)=CC2=O)C=C(Cl)C=C1
InChi Code
InChI=1S/C12H6Cl2O2/c13-7-1-3-11(14)9(5-7)10-6-8(15)2-4-12(10)16/h1-6H
InChi Key
ZKHFYORNAYYOTM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-22480-1 |
|---|---|
| Featured | No |
| Supplier Part Number | 22480-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 79756-69-7 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |