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Cayman Sphinganine-1-phosphate (d18:0)
List Price $120.00 Your Price $120.00
Cayman Sphinganine-1-phosphate (d18:0) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-22500-1
MFG.PART: 22500-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Sphinganine-1-phosphate is an intermediate in the metabolism of glycosphingolipids and sphingolipids. It acts as an antagonist at the sphingosine-1-phosphate (S1P1/EDG-1) receptor (Ki = 15 nM). Sphinganine-1-phosphate prevents liver and kidney damage following hepatic ischemia and reperfusion injury in mice at doses lower than 0.1 and 0.2 mg/kg when administered prior to or following reperfusion, respectively. It has antifibrotic effects in scleroderma fibroblasts through normalization of PTEN protein levels, collagen and matrix metalloproteinase-1 (MMP-1) expression, and Smad3 phosphorylation.,
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2(S)-amino-1,3(R)-
CAS Number
19794-97-9
Synonyms
- C18-dihydro Sphingosine-1-phosphate
- D-erythro-Sphinganine-1-phosphate
- dihydro-D-erythro-Sphingosine-1-phosphate
Molecular Formula
C18H40NO5P
Formula Weight
381.5
Purity
≥95%
Formulation
A crystalline solid
Solubility
- 0.3 M NaOH: 4 mg/mL
- DMF: <50 µg/mL
- DMSO: <50 µg/mL
- Ethanol: <50 µg/mL
- PBS (pH 7.2): <50 µg/mL
SMILES
N[C@H]([C@H](O)CCCCCCCCCCCCCCC)COP(O)(O)=O
InChi Code
InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/t17-,18+/m0/s1
InChi Key
YHEDRJPUIRMZMP-ZWKOTPCHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-22500-1 |
|---|---|
| Supplier Part Number | 22500-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 19794-97-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |