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Cayman 740 Y-P (trifluoroacetate salt)
List Price
$253.00
Your Price
$253.00
Cayman 740 Y-P (trifluoroacetate salt) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-22598-1
MFG.PART:
22598-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
740 Y-P is a synthetic phosphopeptide activator of PI3K., It contains amino acids from the Antennapedia protein, which acts as a cellular internalization sequence, followed by a sequence from PDGFR that is recognized by the SH2 domain of PI3K. 740 Y-P (15 µM) increases phosphorylation of PI3K, mammalian target of rapamycin (mTOR), and glycogen synthase kinase 3β (GSK3β) in HepG2 hepatocellular carcinoma cells. It prevents glucose-oxygen deprivation-induced decreases in viability of primary rat hippocampal cells in an in vitro model of ischemia when used at a concentration of 1 µM. 740 Y-P (1 µM), in combination with the thrombopoietin receptor (TPOR) agonist butyzamide, hematopoietic stem cell (HSC) self-renewal agonist UM171, and polymer PCL-PVAc-PEG, has been used to expand isolated human umbilical cord blood HSCs ex vivo for up to 30 days.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
L-arginyl-
Synonyms
- Y-P 740
Molecular Formula
C141H222N43O39PS3 • XCF3COOH
Formula Weight
3270.7
Purity
≥85%
Formulation
A crystalline solid
Peptide Sequence
RQIKIWFQNRRMKWKKSDGG-[pY]-MDMS
Solubility
- DMSO: 20 mg/mL
- DMSO:PBS (pH 7.2) (1:2): 0.3 mg/mL
λmax
210, 221, 281 nm
SMILES
[H]N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CCCCN)C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CO)C(O)=O)=O)CCSC)=O)CC(O)=O)=O)CCSC)=O)CC1=CC=C(OP(O)(O)=O)C=C1)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)CC2=CNC3=C2C=CC=C3)=O)=O)CCSC)=O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)CC5=CNC6=C5C=CC=C6)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C141H222N43O39PS3.C2HF3O2/c1-8-75(3)114(184-128(208)94(46-48-108(148)188)164-116(196)84(146)32-25-56-156-139(150)151)136(216)174-90(38-20-24-55-145)127(207)183-115(76(4)9-2)137(217)180-101(65-80-70-160-86-34-16-14-31-83(80)86)132(212)175-99(62-77-28-11-10-12-29-77)130(210)170-93(45-47-107(147)187)123(203)177-102(66-109(149)189)133(213)169-92(40-27-58-158-141(154)155)119(199)167-91(39-26-57-157-140(152)153)120(200)171-95(49-59-225-5)124(204)166-88(36-18-22-53-143)121(201)176-100(64-79-69-159-85-33-15-13-30-82(79)85)131(211)168-87(35-17-21-52-142)118(198)165-89(37-19-23-54-144)122(202)181-105(73-185)135(215)178-103(67-112(192)193)117(197)162-71-110(190)161-72-111(191)163-98(63-78-41-43-81(44-42-78)223-224(220,221)222)129(209)172-96(50-60-226-6)125(205)179-104(68-113(194)195)134(214)173-97(51-61-227-7)126(206)182-106(74-186)138(218)219;3-2(4,5)1(6)7/h10-16,28-31,33-34,41-44,69-70,75-76,84,87-106,114-115,159-160,185-186H,8-9,17-27,32,35-40,45-68,71-74,142-146H2,1-7H3,(H2,147,187)(H2,148,188)(H2,149,189)(H,161,190)(H,162,197)(H,163,191)(H,164,196)(H,165,198)(H,166,204)(H,167,199)(H,168,211)(H,169,213)(H,170,210)(H,171,200)(H,172,209)(H,173,214)(H,174,216)(H,175,212)(H,176,201)(H,177,203)(H,178,215)(H,179,205)(H,180,217)(H,181,202)(H,182,206)(H,183,207)(H,184,208)(H,192,193)(H,194,195)(H,218,219)(H4,150,151,156)(H4,152,153,157)(H4,154,155,158)(H2,220,221,222);(H,6,7)/t75-,76-,84-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,114-,115-;/m0./s1
InChi Key
LJHHGCCOGDBGSX-PTPSHLCPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-22598-1 |
|---|---|
| Supplier Part Number | 22598-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1236188-16-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |