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Cayman VU0364770
List Price $479.00 Your Price $479.00
Cayman VU0364770 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-22927-50
MFG.PART: 22927-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
VU0364770 is a positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4; EC50 = 1.1 µM in a calcium mobilization assay).1 It is also a positive allosteric modulator of mGluR6 (EC50 = 6.8 µM) and an antagonist of mGluR5 (IC50 = 17.9 µM). VU0364770 binds to monoamine oxidase A (MAO-A) and MAO-B (Kis = 8.5 and 7.2 µM, respectively), as well as the human norepinephrine transporter in a panel of 68 receptors, ion channels, and transporters at 10 µM. It decreases haloperidol-induced catalepsy and reduces increases in the number of premature reactions in response to a light cue, indicating improved attentional control, in a 6-hydroxydopamine (6-OHDA; Item No. 25330) rat model of Parkinson’s disease when administered at a dose of 56.6 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-(3-chloro
CAS Number
61350-00-3
Molecular Formula
C12H9ClN2O
Formula Weight
232.7
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMF:PBS (pH 7.2) (1:1): 0.5 mg/mL
- DMSO: 25 mg/mL
- Ethanol: 5 mg/mL
λmax
219, 277 nm
SMILES
ClC1=CC(NC(C2=NC=CC=C2)=O)=CC=C1
InChi Code
InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)
InChi Key
SUYUTNCKIOLMAJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-22927-50 |
|---|---|
| Supplier Part Number | 22927-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 61350-00-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |