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Cayman D-64131
List Price $635.00 Your Price $635.00
Cayman D-64131 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-22944-50
MFG.PART: 22944-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
D-64131 is an antimitotic agent that inhibits polymerization of microtubules with an IC50 value of 0.53 µM in a radioligand binding assay using purified tubules from bovine brain.1 It arrests the cell cycle at the g2/M transition (IC50 = 92 nM) and is preferentially cytotoxic to cycling cells. It has antiproliferative activity in cancer cell lines derived from various tissues and organs (IC50s = 24-144 nM) and in cell lines resistant to other tubulin inhibitors (IC50s = 20-77 nM). D-64131 (200 and 400 mg/kg) is also efficacious in reducing tumor growth in a mouse xenograft model of human amelanoic melanoma.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(5-methoxy-1H
CAS Number
74588-78-6
Molecular Formula
C16H13NO2
Formula Weight
251.3
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 33 mg/mL
- DMF:PBS (pH 7) (1:10): 0.16 mg/mL
- DMSO: 25 mg/mL
λmax
324 nm
SMILES
COC1=CC=C2C(C=C(C(C3=CC=CC=C3)=O)N2)=C1
InChi Code
InChI=1S/C16H13NO2/c1-19-13-7-8-14-12(9-13)10-15(17-14)16(18)11-5-3-2-4-6-11/h2-10,17H,1H3
InChi Key
ICMIJSRDISNKOC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-22944-50 |
|---|---|
| Supplier Part Number | 22944-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 74588-78-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |