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Cayman CID-5721353
List Price $36.00 Your Price $36.00
Cayman CID-5721353 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-22967-1
MFG.PART: 22967-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
CID-5721353 is an inhibitor of the transcriptional repressor B cell lymphoma 6 (Bcl-6; Ki = 147 µM). It is selective for Bcl-6 over Kaiso, hypermethylated in cancer 1 (HIC1), and promyelocytic leukemia zinc finger (PLZF) at 50 µM. CID-5721353 is cytotoxic against Bcl-6-dependent SU-DLH-6, SU-DLH-4, Farage, OCI-LY7, OCI-LY1, and OCI-LY10 diffuse large B cell lymphoma (DLBCL) cells (GI50s = 0.024-0.936 mm) but not Bcl-6-independent Toledo or OCI-LY4 DLBCL cells (GI50 = >15 mm for both). It increases expression of the Bcl-6 target genes ATR, TP53, CD69, p21, and CD44 in SU-DLH-6 and SU-DHL-4 cells when used at a concentration of 50 µM. CID-5721353 (50 mg/kg) reduces tumor growth in OCI-LY7 and SU-DHL-6 mouse xenograft models.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[5-(5-bromo-
CAS Number
301356-95-6
Molecular Formula
C15H9BrN2O6S2
Formula Weight
457.3
Purity
≥98%
Formulation
A solid
Solubility
- Acetonitrile: Soluble
- DMSO: Soluble
SMILES
BrC1=CC=C2C(/C(C(N2)=O)=C3C(N(C(C(O)=O)CC(O)=O)C(S\3)=S)=O)=C1
InChi Code
InChI=1S/C15H9BrN2O6S2/c16-5-1-2-7-6(3-5)10(12(21)17-7)11-13(22)18(15(25)26-11)8(14(23)24)4-9(19)20/h1-3,8H,4H2,(H,17,21)(H,19,20)(H,23,24)/b11-10-
InChi Key
QGNRETMYLHRUBB-KHPPLWFESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-22967-1 |
|---|---|
| Supplier Part Number | 22967-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 301356-95-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |