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Cayman ICA 069673
List Price
$796.00
Your Price
$796.00
Cayman ICA 069673 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-22995-50
MFG.PART:
22995-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
ICA 069673 is a heteromeric Kv7 channel activator.1,2 It is selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively) and also activates Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5 channels in a dose-dependent manner.2 ICA 069673 has no activity against hERG, Nav1.5, and Kv7.1 cardiac ion channels (IC50s = >30 μM).1 Oral administration of ICA 069673 increases latency to first tonic-clonic seizure in the rat maximal electroshock and pentylentetrazol-induced seizure models (ED50s = 1.5 and <1 mg/kg, respectively).1 Formulations containing ICA 069673 are under clinical investigation for the treatment of epilepsy.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-(2-chloro-5
CAS Number
582323-16-8
Molecular Formula
C11H6ClF2N3O
Formula Weight
269.6
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 30 mg/mL
λmax
267 nm
SMILES
ClC1=NC=C(NC(C2=CC(F)=C(F)C=C2)=O)C=N1
InChi Code
InChI=1S/C11H6ClF2N3O/c12-11-15-4-7(5-16-11)17-10(18)6-1-2-8(13)9(14)3-6/h1-5H,(H,17,18)
InChi Key
IIBSHMFXVWTQSJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-22995-50 |
|---|---|
| Supplier Part Number | 22995-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 582323-16-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |