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Cayman Vercirnon
List Price $90.00 Your Price $90.00
Cayman Vercirnon - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-23131-1
MFG.PART: 23131-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Vercirnon is an orally bioavailable antagonist of chemokine receptor 9 (CCR9) with an IC50 value of 5.4 nM for inhibition of CCL25-induced calcium mobilization in Molt-4 cells. It is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s = >10 µM for all). It also inhibits CCL25-induced Molt-4 chemotaxis in 0.1% BSA/HBSS and in 100% human AB serum (IC50s = 3.5 and 33.4 nM, respectively), as well as chemotaxis of human T cells stimulated by retinoic acid (RA) and mouse and rat thymocytes. Vercirnon binds allosterically to the intracellular side of CCR9 and prevents g protein coupling.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[4-chloro-2
CAS Number
698394-73-9
Synonyms
- CCX282-B
- GSK1605786
Molecular Formula
C22H21ClN2O4S
Formula Weight
444.9
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMSO: 25 mg/mL
λmax
226, 313 nm
SMILES
O=C(C(C=C1)=CC=[N]1=O)C(C=C(Cl)C=C2)=C2N[S](=O)(C3=CC=C(C(C)(C)C)C=C3)=O
InChi Code
InChI=1S/C22H21ClN2O4S/c1-22(2,3)16-4-7-18(8-5-16)30(28,29)24-20-9-6-17(23)14-19(20)21(26)15-10-12-25(27)13-11-15/h4-14,24H,1-3H3
InChi Key
JRWROCIMSDXGOZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-23131-1 |
|---|---|
| Supplier Part Number | 23131-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 698394-73-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |