Cayman Nicotinamide riboside

Nicotinamide riboside is a riboside form of nicotinamide (Item No. ) that is found in trace amounts in yeast-containing and milk-derived products. It is a precursor of NAD⁺ (Item No. ) and a source of vitamin B₃ (niacin). Nicotinamide riboside increases intracellular and mitochondrial NAD⁺ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1,000 μM. It also decreases acetylation of FOXO1 and SOD2, which are substrates of sirtuin 1 (SIRT1) and SIRT3, respectively, but not the SIRT2 substrate tubulin, indicating nicotinamide riboside selectively enhances SIRT1 and 3 deacetylase activity. Nicotinamide riboside (400 mg/kg per day) increases NAD⁺ levels in liver and skeletal muscle and prevents body weight gain in mice fed a high-fat diet. It also increases NAD⁺ in the cerebral cortex and reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.

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