We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman Nateglinide
List Price $143.00 Your Price $143.00
Cayman Nateglinide - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-23320-1
MFG.PART: 23320-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Nateglinide is a hypoglycemic agent.,, It induces insulin and somatostatin release from perfused rat pancreas when used at concentrations ranging from 0.03 to 3 μM. Nateglinide (3 µM) increases intracellular calcium levels in isolated rat pancreatic β cells, an effect that can be inhibited by the L-type calcium channel blocker nitrendipine (Item No. ). Nateglinide-induced secretion of insulin and somatostatin and calcium influx is also reversed by the potassium channel activator diazoxide (Item No. 14576). Oral administration of nateglinide (1.6 mg/kg) reduces blood glucose levels by 20% in fasted mice. It also decreases blood glucose levels in an oral glucose tolerance test in normal rats, genetically diabetic KK mice, and a rat model of diabetes induced by streptozotocin (STZ; Item No. ). Formulations containing nateglinide have been used in the treatment of type 2 diabetes.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[[trans-4-
CAS Number
105816-04-4
Synonyms
- A-4166
- SDZ-DJN 608
Molecular Formula
C19H27NO3
Formula Weight
317.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 30 mg/mL
λmax
207 nm
SMILES
CC(C)[C@@H]1CC[C@@H](C(N[C@@H](C(O)=O)CC2=CC=CC=C2)=O)CC1
InChi Code
InChI=1S/C19H27NO3/c1-13(2)15-8-10-16(11-9-15)18(21)20-17(19(22)23)12-14-6-4-3-5-7-14/h3-7,13,15-17H,8-12H2,1-2H3,(H,20,21)(H,22,23)/t15-,16-,17-/m1/s1
InChi Key
OELFLUMRDSZNSF-BRWVUGGUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-23320-1 |
|---|---|
| Supplier Part Number | 23320-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 105816-04-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |