Cayman WAY-200070

WAY-200070 is a potent and selective agonist of estrogen receptor β (ERβ; IC₅₀s = 2 and 187 nM for human full-length ERβ and ERα, respectively). WAY-200070 (30 mg/kg, s.c. in mice) induces nuclear translocation of ERβ and increases c-fos activation and dopamine levels in the striatum four hours after administration. At the same dose, it decreases depressive-like behavior in the tail suspension test. It has anxiolytic effects in mice using the four-plate and stress-induced hyperthermia tests and in zebrafish larvae using a light-dark choice behavior test.^, In addition, WAY-200070 improves glucose and insulin sensitivity in mouse models of diabetes.

WARNING This product is not for human or veterinary use.