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Cayman Sal-003
List Price $171.00 Your Price $171.00
Cayman Sal-003 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-23414-10
MFG.PART: 23414-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Sal-003 dose-dependently prevents dephosphorylation of eukaryotic translation initiation factor 2 subunit α (eIF2α). It is a more potent derivative of salubrinal (Item No. ) that increases eIF2α phosphorylation in mouse embryonic fibroblasts (MEFs) when used at a concentration of 10 µM. It impairs late-phase long-term potentiation (LTP) in hippocampal slices from wild-type, but not ATF4 knockout, mice. When infused into the dorsal hippocampus post-training, Sal-003 impairs contextual fear memory in rats.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(2E)-3-phenyl-
CAS Number
1164470-53-4
Molecular Formula
C18H15Cl4N3OS
Formula Weight
463.2
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:2): 0.33 mg/mL
λmax
217, 277 nm
SMILES
ClC1=CC=C(NC(NC(C(Cl)(Cl)Cl)NC(/C=C/C2=CC=CC=C2)=O)=S)C=C1
InChi Code
InChI=1S/C18H15Cl4N3OS/c19-13-7-9-14(10-8-13)23-17(27)25-16(18(20,21)22)24-15(26)11-6-12-4-2-1-3-5-12/h1-11,16H,(H,24,26)(H2,23,25,27)/b11-6+
InChi Key
TVNBASWNLOIQML-IZZDOVSWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-23414-10 |
|---|---|
| Supplier Part Number | 23414-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 1164470-53-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |