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Cayman Antazoline (hydrochloride)
List Price $86.00 Your Price $86.00
Cayman Antazoline (hydrochloride) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-23415-1
MFG.PART: 23415-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Antazoline is a histamine H1 receptor antagonist that binds to histamine H1receptors with a Ki value of 38.4 nM in cell membranes expressing human recombinant H1 receptors. Antazoline reduces histamine-induced IL-6 and IL-8 production in human conjunctival epithelial cells (IC50s = 1 and 0.652 μM, respectively). It completely prevents anaphylaxis in rabbits sensitized to egg albumin and increases survival in a guinea pig model of histamine-induced bronchospasm. Antazoline (10-30 µM) eliminates atrial fibrillation induced by acetylcholine and isoproterenol (Item No. ) in isolated rabbit hearts by increasing the atrial effective refractory period and interatrial conduction time in a dose-dependent manner. Antazoline also binds to NMDA receptors (Ki = 13 μM) and reduces glutamate-induced toxicity in cerebellar granule cells (EC50 = 13 μM).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4,5-dihydro-
CAS Number
2508-72-7
Synonyms
- 2-(N-Benzylanilinomethyl)-2-imidazoline
Molecular Formula
C17H19N3 • HCl
Formula Weight
301.8
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/mL
- DMSO: 25 mg/mL
- Ethanol: 25 mg/mL
- PBS (pH 7.2): 10 mg/mL
λmax
244, 289 nm
SMILES
C1(CN(CC2=NCCN2)C3=CC=CC=C3)=CC=CC=C1.Cl
InChi Code
InChI=1S/C17H19N3.ClH/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16;/h1-10H,11-14H2,(H,18,19);1H
InChi Key
SWKDMSRRIBZZAY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-23415-1 |
|---|---|
| Supplier Part Number | 23415-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2508-72-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |