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Cayman B-RAF IN 1
List Price $69.00 Your Price $69.00
Cayman B-RAF IN 1 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-23434-1
MFG.PART: 23434-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
B-RAF IN 1 is an inhibitor of B-RAF (IC50 = 24 nM) that also inhibits C-RAF (IC50 = 25 nM). It is selective over 13 other kinases, including PKCα, IKKβ, and PI3Kα, at concentrations greater than 2 µM, but does inhibit p38α and CAMKII (IC50s = 216 and 822 nM, respectively). B-RAF IN 1 binds to B-RAF in the inactive conformation based on co-crystallization with the wild-type enzyme. It inhibits proliferation of WM 266-4 and HT29 cells with IC50 values of 920 and 780 nM, respectively.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[3-[3-[4-
CAS Number
950736-05-7
Synonyms
- B-RAF Inhibitor 1
Molecular Formula
C29H24F3N5O
Formula Weight
515.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 14 mg/mL
- DMSO: 33 mg/mL
- Ethanol: 1 mg/mL
λmax
269 nm
SMILES
CN(C)CC(C=C1)=CC=C1C2=C3N=CC=C(C4=CC=CC(NC(C5=CC=CC(C(F)(F)F)=C5)=O)=C4)N3N=C2
InChi Code
InChI=1S/C29H24F3N5O/c1-36(2)18-19-9-11-20(12-10-19)25-17-34-37-26(13-14-33-27(25)37)21-5-4-8-24(16-21)35-28(38)22-6-3-7-23(15-22)29(30,31)32/h3-17H,18H2,1-2H3,(H,35,38)
InChi Key
AIWJVLQNYNCDSL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-23434-1 |
|---|---|
| Supplier Part Number | 23434-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 950736-05-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |