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Cayman MI 2
List Price $36.00 Your Price $36.00
Cayman MI 2 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-23437-1
MFG.PART: 23437-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
MI 2 is an inhibitor of the paracaspase MALT1 with an IC50 value of 5.84 μM in a fluorescence assay. It inhibits the growth of MALT1-dependent activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) cell lines (GI50s = 0.2, 0.5, 0.4, and 0.4 μM for HBL-1, TMD8, OCI-Ly3, and OCI-Ly10 cells, respectively). MI 2 inhibits cleavage of the MALT1 target protein CYLD in a dose-dependent manner in HBL-1 cells but does not inhibit caspase-3, caspase-8, and caspase-9, which are structurally similar to MALT1. MI 2 (25 mg/kg, i.v.) reduces tumor size in TMD8 and HBL-1 mouse xenograft models.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-chloro-N-
CAS Number
1047953-91-2
Molecular Formula
C19H17Cl3N4O3
Formula Weight
455.7
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 33 mg/mL
- DMSO: 33 mg/mL
- DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL
- Ethanol: 16 mg/mL
λmax
253 nm
SMILES
O=C(CCl)NC(C=C1)=CC=C1N2C(C3=CC=C(Cl)C(Cl)=C3)=NC(OCCOC)=N2
InChi Code
InChI=1S/C19H17Cl3N4O3/c1-28-8-9-29-19-24-18(12-2-7-15(21)16(22)10-12)26(25-19)14-5-3-13(4-6-14)23-17(27)11-20/h2-7,10H,8-9,11H2,1H3,(H,23,27)
InChi Key
TWJGQZBSEMDPQP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-23437-1 |
|---|---|
| Supplier Part Number | 23437-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1047953-91-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |