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Cayman WHI-P180
List Price $753.00 Your Price $753.00
Cayman WHI-P180 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-23452-5
MFG.PART: 23452-5
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
WHI-P180 is a multi-kinase inhibitor with IC50 values of 4.5 and 66 nM for the human proto-oncogene RET and kinase insert domain receptor (KDR), respectively.1 It also inhibits EGFR (IC50 = 4 μM) and binds to tau-tubulin kinase 1 (TTBK1; Kds = 0.46 and 0.24 μM for phosphorylated and non-phosphorylated TTBK1, respectively).2,3 WHI-P180 inhibits JAK3 and JAK3-driven graft versus host disease responses in mice receiving allogenic bone marrow and splenocyte grafts.2,4 WHI-P180 (25 mg/kg, i.p) inhibits IgE-induced vascular hyperpermeability in a mouse model of passive anaphylaxis.5
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3-[(6,7-dimeth
CAS Number
211555-08-7
Synonyms
- Janex 3
Molecular Formula
C16H15N3O3
Formula Weight
297.3
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 25 mg/mL
- DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL
- DMSO: 15 mg/mL
λmax
203, 228, 252, 335 nm
SMILES
COC1=C(OC)C=C(C(NC2=CC=CC(O)=C2)=NC=N3)C3=C1
InChi Code
InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-4-3-5-11(20)6-10/h3-9,20H,1-2H3,(H,17,18,19)
InChi Key
BNDYIYYKEIXHNK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-23452-5 |
|---|---|
| Supplier Part Number | 23452-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 211555-08-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |