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Cayman Al 082D06
List Price
$49.00
Your Price
$49.00
Cayman Al 082D06 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-23455-1
MFG.PART:
23455-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Al 082D06 is a non-steroidal antagonist of the glucocorticoid receptor (GR; Ki = 210 nM; EC50 = 0.3 nM in a luciferase assay). It is selective for GR over the androgen, progesterone, mineralocorticoid, and estrogen receptors with Ki values greater than 4, 3, 3, and 10 µM, respectively. Al 082D06 inhibits transcriptional activation induced by glucocorticoids and reverses dexamethasone-mediated repression of gene expression in a luciferase reporter assay. It blocks GR binding to DNA in vitro when induced by either dexamethasone (Item No. ) or mifepristone (Item No. ). In contrast to the steroid-type GR antagonists ZK-299 and mifepristone, GR bound to Al 082D06 does not compete with a constitutively active GR.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4,4-[(2-
CAS Number
256925-03-8
Molecular Formula
C23H24ClN3O2
Formula Weight
409.9
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/mL
- DMF:PBS(pH7.2) (1:2): 0.33 mg/mL
- DMSO: 2.5 mg/mL
λmax
268 nm
SMILES
CN(C)C1=CC=C(C(C2=C(Cl)C=CC([N+]([O-])=O)=C2)C3=CC=C(N(C)C)C=C3)C=C1
InChi Code
InChI=1S/C23H24ClN3O2/c1-25(2)18-9-5-16(6-10-18)23(17-7-11-19(12-8-17)26(3)4)21-15-20(27(28)29)13-14-22(21)24/h5-15,23H,1-4H3
InChi Key
IPICUXHYPAMJNC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-23455-1 |
|---|---|
| Supplier Part Number | 23455-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 256925-03-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |