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Cayman SW044248
List Price $125.00 Your Price $125.00
Cayman SW044248 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-23459-10
MFG.PART: 23459-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
SW044248 is a DNA topoisomerase I inhibitor that exhibits selective cytotoxicity across a panel of 46 non-small cell lung cancer cell (NSCLC) lines (IC50s = ~2 μM for HCC4017, H292, and H1819 cells versus >20 μM for the remaining cell lines). It induces cleavage of poly(ADP-ribose) polymerase (PARP) and caspase-3 and blocks DNA replication, RNA transcription, and protein translation in HCC4017 susceptible-, but not HBEC30KT resistant-, cells in a dose-dependent manner. SW044248 inhibits the ability of recombinant topoisomerase 1 to relax supercoiled DNA in a dose-dependent manner and topoisomerase 1 knockdown rescues HCC4017 cells from SW044248 cytotoxicity. SW044248 is less cytotoxic against HCC4017 cells transfected with CDKN1, a protein overexpressed in SW044248-resistant NSCLC cells, indicating a role for CDKN1A in SW044248 resistance.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[(5-ethyl-
CAS Number
522650-83-5
Molecular Formula
C22H23N5O2S
Formula Weight
421.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 5 mg/mL
- DMSO: 5 mg/mL
- Ethanol: 1 mg/ mL
λmax
202, 267, 344 nm
SMILES
CCN1C2=NC(SC(CC)C(NC3=C(OC)C=CC=C3)=O)=NN=C2C4=CC=CC=C14
InChi Code
InChI=1S/C22H23N5O2S/c1-4-18(21(28)23-15-11-7-9-13-17(15)29-3)30-22-24-20-19(25-26-22)14-10-6-8-12-16(14)27(20)5-2/h6-13,18H,4-5H2,1-3H3,(H,23,28)
InChi Key
PEVRGVRHMMZNGI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-23459-10 |
|---|---|
| Supplier Part Number | 23459-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 522650-83-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |