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Cayman ATN-224
List Price $152.00 Your Price $152.00
Cayman ATN-224 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-23553-10
MFG.PART: 23553-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
ATN-224 is a choline salt of tetrathiomolybdate and an inhibitor of superoxide dismutase 1 (SOD1; IC50s = 2.91 and 3.51 µM in human and mouse blood cells, respectively, in vitro).1 ATN-224 reduces the viability of cultured oxidative stress-resistant WEHI7.2 murine thymic lymphoma cells (EC50s = 5-6 nM) and human diffuse large B cell lymphoma cell lines (EC50s = 9.73-105.61 nM) independently of Bcl-2 and Bcl-xL.2,3 In vivo, ATN-224 (0.7 mg/kg) chelates copper to stabilize an antitumor viral vector, enhancing its efficacy against lung metastases in mice.4 It also inhibits angiogenesis in a mouse model (IC50s = 1.50-3 mg/kg via gavage).1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-hydroxy-
CAS Number
649749-10-0
Synonyms
- Bis-Choline Tetrathiomolybdate
Molecular Formula
C5H14NO • 1/2MoS4
Formula Weight
432.5
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMSO: 20 mg/mL
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
λmax
242, 315, 468 nm
SMILES
C[N+](C)(C)CCO.C[N+](C)(C)CCO.S=[Mo-2](=S)(=S)=S
InChi Code
InChI=1S/2C5H14NO.Mo.4S/c2*1-6(2,3)4-5-7;;;;;/h2*7H,4-5H2,1-3H3;;;;;/q2*+1;-2;;;;
InChi Key
XTDZSQBNDXNMJY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-23553-10 |
|---|---|
| Supplier Part Number | 23553-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 649749-10-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |