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Cayman Tazarotene
List Price $68.00 Your Price $68.00
Cayman Tazarotene - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-23559-10
MFG.PART: 23559-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Tazarotene is a retinoid prodrug of tazarotenic acid (Item No. ). It is metabolized by esterases in vivo to its active free acid form. Tazarotene (1 μM) inhibits proliferation of and collagen synthesis by human dermal fibroblasts in vitro. It also downregulates markers of keratinocyte differentiation, keratinocyte proliferation, and inflammation and upregulates tazarotene-induced gene 1 (TIG1) and TIG2 in patient-derived psoriatic lesion samples following topical administration. Tazarotene (0.1% per day, topical) induces complete reduction in skin utricle diameter in the Rhino mouse, which is a model used to test retinoid activity because its skin contains keratinized pilosebaceous structures. It also decreases basal cell carcinoma number and size in a Ptch1+/- mouse model of ultraviolet- or ionizing radiation-induced skin cancer when administered topically at a dose of 0.1% per day. Formulations containing tazarotene have been used in the treatment of psoriasis, acne, and sun-damaged skin.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-[2-(3,4-
CAS Number
118292-40-3
Synonyms
- AGN 190168
Molecular Formula
C21H21NO2S
Formula Weight
351.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL
λmax
259, 352 nm
SMILES
O=C(OCC)C1=CC=C(C#CC2=CC(C(C)(C)CCS3)=C3C=C2)N=C1
InChi Code
InChI=1S/C21H21NO2S/c1-4-24-20(23)16-7-9-17(22-14-16)8-5-15-6-10-19-18(13-15)21(2,3)11-12-25-19/h6-7,9-10,13-14H,4,11-12H2,1-3H3
InChi Key
OGQICQVSFDPSEI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-23559-10 |
|---|---|
| Supplier Part Number | 23559-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 118292-40-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |