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Cayman Sulfamethoxazole
List Price $134.00 Your Price $134.00
Cayman Sulfamethoxazole - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-23613-100
MFG.PART: 23613-100
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Sulfamethoxazole is a sulfonamide antibiotic. It inhibits growth of E. coli (MIC = 10 μg/mL) and clinical isolates of methicillin-resistant S. aureus (MRSA; MICs = 25-50 μg/mL)., Sulfamethoxazole, in combination with trimethoprim (Item No. ) at a ratio of 20:1, inhibits growth of MRSA in vivo in mice (MIC = 0.8 μg/mL; ED50s = 6.4 and 9.6 mg/kg for two MRSA strains). In a mouse model of urinary tract infection with E. coli, a combination of sulfamethoxazole and trimethoprim decreases recurrent infection when administered for 10 days. Sulfamethoxazole acts by inhibiting dihydropteroate synthase (DHPS), which converts a pteridine and 4-aminobenzoic acid (PABA; Item No. ) to dihydropteroate, an intermediate in folate biosynthesis. It inhibits recombinant P. carinii DHPS (IC50 = 23 nM; Ki = 7.5 nM) and folate biosynthesis in situ by 48.6%. Formulations containing sulfamethoxazole and trimethoprim have been used to treat bronchitis, prostatitis, and urinary tract infections among other infectious conditions.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-amino-N-(5-
CAS Number
723-46-6
Synonyms
- NSC 147832
- Ro 4-2130
Molecular Formula
C10H11N3O3S
Formula Weight
253.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 50 mg/mL
- DMSO: 50 mg/mL
- DMSO:PBS (pH 7.2) (1:2): 0.5 mg/mL
- Ethanol: 0.25 mg/mL
λmax
271 nm
SMILES
NC1=CC=C(S(NC2=NOC(C)=C2)(=O)=O)C=C1
InChi Code
InChI=1S/C10H11N3O3S/c1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h2-6H,11H2,1H3,(H,12,13)
InChi Key
JLKIGFTWXXRPMT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-23613-100 |
|---|---|
| Supplier Part Number | 23613-100 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 723-46-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |